Understanding the basic components of life
Structural biology seeks to understand the underlying atomic structures of proteins and other macromolecules, which are at the basis of living organisms (along with DNA, lipids and sugars).
GIANT offers researchers the enormous advantage of high-powered sources of synchrotron (ESRF) and neutron (ILL) rays. Key research organizations, including IBS and EMBL, have joined forces with ESRF and ILL in the Partnership for Structural Biology (PSB) to study proteins with biomedical potential, a unique partnership in the field of structural biology.
In the years to come, innovation will focus on:
- Unstructured proteins, often involved in neurodegenerative diseases
- Membrane proteins, which are the gateways to cells and the targets of numerous medications
- Large assemblages of cell proteins, such as viruses.
Upstream research will contribute to developments in environmental and energy management, as well as health and agriculture:
- Functional and structural studies of proteins, opening the way to new means for combating bacteria
- Understanding of viruses, providing new insights into the understanding of infection
- The nano-workings of organisms living in extreme conditions, providing new insights for nano and micro-technologies.
- EMBL : European Molecular Biology Laboratory
- IBS – Institut de Biologie Structurale Jean-Pierre Ebel
- BIG – Biosciences and Biotechnology Institute of Grenoble
- PSB – Partnership for Structural Biology
- UVHCI – Unit of Virus Host Cell Interactions
- LyonBiopôle, a world-class competitive cluster: http://www.lyonbiopole.org/
Structure of a protein that transports nucleotides through the membrane of a mitochondrion. Copyright IBS